THE HISTONE H4 PROTEOFORM DYNAMICS IN RESPONSE TO SUV4-20 INHIBITION REVEALS SINGLE MOLECULE MECHANISMS OF INHIBITOR RESISTANCE

The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance

Abstract Background The dynamics of histone post-translational modifications (PTMs) are sparsely described, Hand Sanitizers especially in their true physiological context of proteoforms (single histone molecules harboring combinations of PTMs).Methods Here we time-resolve the response of cells to SUV4-20 methyltransferase inhibition and unbiasedly

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An online case-based teaching and assessment program on clinical history-taking skills and reasoning using simulated patients in response to the COVID-19 pandemic

Abstract Background The COVID-19 pandemic has created unprecedented challenges for medical students and educators worldwide.Groups 1, 2 and 3 of year 3, semester 2 medical students at the Royal College of Surgeons in Ireland (n = 275) had only completed 2, 5 and 7 Football - Shoes - Men weeks, respectively, of their scheduled 10-week clinical medic

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Antibiotic resistance profile of gram-negative bacteria isolated from dog nasal swab samples, and antibacterial and antioxidant activities of aqueous extracts of Alpinia purpurta (Vieill.) K. Schum (Zingiberaceae)

The indiscriminate use of antibiotics in veterinary medicine and their negligent use among dog owners have contributed to the rise of antibiotic resistance in microorganisms found in pets.In addition, the search for medicinal plants with antibacterial properties has made the evaluation of aqueous extracts of Alpinia purpurata (Vieill.) K.Schum an i

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